Nuclear Medicine Therapy presents the state of the art in targeted radionuclide therapy, both in clinical practice and contemporary clinical investigation and trials. With contributions from an internationally-distinguished group of physicians and scientists, the book is devoted entirely to the use of nuclear medicine techniques and technology for therapy of malignant and benign diseases. Individual chapters cover the scientific principles and clinical applications of radionuclide therapy and the state of clinical trials of agents currently under investigation in the therapy of tumors involving virtually every organ system. Due to overlapping interest in techniques, indications, and clinical use, the development of radionuclide therapy attracts considerable input from other medical specialists whose collaboration is essential, including radiation and medical oncologists, hematologists, diagnostic radiologists, hepatologists, endocrinologists, and rheumatologists. And because radionuclide therapy is a rapidly evolving field of nuclear medicine, it is the aim of this volume to appeal to all specialists involved in targeted radionuclide therapy and to contribute to the standardization of the practice globally.
Part I: Radionuclide Therapy of Malignant Diseases -- Radioimmunotherapy of Lymphoma -- Radionuclide Therapy of Leukemias -- Radiophosphorus Treatment of Myeloproliferative Neoplasms -- Radionuclide Therapy of Neuroendocrine Tumors -- Radionuclide Therapy of Bone Metastases -- Radionuclide Therapy in Melanoma -- Radioimmunotherapy in Brain Tumors -- Radioiodine Therapy of Differentiated Thyroid Cancer -- Medullary Thyroid Carcinoma -- Local Accelerated Radionuclide Breast Irradiation: Avidin-Biotin Targeting System -- Radiomicrosphere Therapy of Liver Tumors -- Trans-Arterial I-131 Lipiodol Therapy of Liver Tumors -- Antibody-Targeted Therapeutic Radionuclides in the Management of Colorectal Cancer -- Radioimmunotherapy of Pancreatic Adenocarcinoma -- Radioimmunotherapy of Renal Cell Carcinoma -- Radioimmunotherapy of Prostate Carcinoma -- Part II: Radionuclide Therapy of Benign Diseases -- Radioiodine Therapy of Benign Thyroid Diseases: Graves’ Disease, Plummer’s Disease, Non-toxic Goiter and Nodules -- Radiosynoviorthesis -- Part III: Special Topics in Radionuclide Therapy -- The Chemistry of Therapeutic Radiopharmaceuticals -- Pretargeting: Advancing the Delivery of Radionuclides -- Radiobiology as Applied to Radionuclide Therapy with an Emphasis on Low Dose Rate Radiation Effects -- Release Criteria and Other Radiation Safety Considerations for Radionuclide Therapy -- Challenges Associated with Radionuclide Therapy and Need for Interdepartmental Collaboration