.

0 (hodnocen0 x )

EB

EB

ONLINE

Cham : Springer International Publishing : Imprint: Springer, 2017

1 online zdroj

ISBN 978-3-319-57193-5 (e-kniha)

ISBN 9783319571911 (print)

Advances in Neurobiology, ISSN 2190-5215 ; 15

Printed edition: ISBN 9783319571911

Part 1: Major Neurodegenerative Conditions -- Alzheimer’s Disease – Insights from Genetic Mouse Models and Current Advances in Human IPSC-Derived Neurons -- Clinical Aspects of Alzheimer’s Disease -- Parkinson’s Disease: Basic Pathomechanisms and a Clinical Overview -- Huntington’s Disease: Pathogenic Mechanisms and Therapeutic Targets -- The Complexity of Clinical Huntington’s Disease: Developments in Molecular Genetics, Neuropathology and Neuroimaging Biomarkers -- Motoneurone Disease – Basic Science -- Motoneurone Disease – Clinical -- Multiple Sclerosis – Basic and Clinical -- Part 2: Other Neurological Conditions -- Schizophrenia—Basic and Clinical -- Stroke – Basic and Clinical -- Epileptic Encephalopathies as Neurodegenerative Disorders -- Neurodegeneration and Pathology in Epilepsy–Clinical and Basic Perspectives -- Prion Disease – Basic and Clinical -- Leukodystrophies – Basic and Clinical -- Traumatic Brain Injury as a Trigger of Neurodegeneration -- Part 3: Key Background and Key Technologies -- Cell Death Mechanisms of Neurodegeneration -- Neuroglia: Functional Paralysis and Reactivity in Alzheimer’s Disease and Other Neurodegenerative Pathologies -- Advances in Neuroimaging for Neurodegenerative Disease -- Gene Linkage and Systems Biology -- Biomarkers in Neurodegenerative Diseases.

Provides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies. The editors bring together contributions from internationally recognized workers in the field to provide an up to date account of how and why molecular and cellular neurobiology is such an important area for clinical neuroscience. Understanding the molecular aspects of a number of neurodegenerative conditions such as Parkinson’s or Alzheimer’s disease for the purpose of improving patient management remains a major challenge of neurobiology be it from the basic or clinical perspective. A strategic evaluation of research contributions and the power of modern methods will help advance knowledge over the next years..

001474024

Contents // Part I Major Neurodegenerative Conditions // 1 Alzheimer’s Disease: Insights from Genetic Mouse Models and Current Advances in Human IPSC-Derived Neurons .. // Anne E. Harasta and Lars M. Ittner // 2 Clinical Aspects of Alzheimer’s Disease... // Fiona Kumfor, Glenda M. Halliday, and Olivier Piguet // 3 Parkinson’s Disease: Basic Pathomechanisms // and a Clinical Overview... // Alastair Noyce and Rina Bandopadhyay // 4 Huntington’s Disease: Pathogenic Mechanisms // and Therapeutic Targets... // Dean J. Wright, Thibault Renoir, Laura J. Gray, and Anthony J. Hannan // 5 The Complexity of Clinical Huntington’s Disease: // Developments in Molecular Genetics, Neuropathology and Neuroimaging Biomarkers... // Lynette J. Tippett, Henry J. Waldvogel, Russell G. Snell, Jean-Paul Vonsattel, Anne B. Young, and Richard L.M. Faull // 6 Motoneuron Disease: Basic Science... // Hristelina Ilieva and Nicholas J. Maragakis // 7 Motoneuron Disease: Clinical... // Hristelina Ilieva and Nicholas J. Maragakis // 8 Multiple Sclerosis: Basic and Clinical... // Katherine Buzzard, Wing Hei Chan, Trevor Kilpatrick, and Simon Murray // Contents // vili // Part II Other Neurological Conditions // 9 Schizophrenia: Basic and Clinical... 255 // Joseph T. Coyle // 10 Stroke: Basic and Clinical... 281 // Tarvinder P. Singh, Jonathan R. Weinstein, and Sean P. Murphy // 11 Epileptic Encephalopathies as Neurodegenerative Disorders... 295 // Ingo Helbig, Markus von Deimling, and Eric D. Marsh

12 Neurodegeneration and Pathology in Epilepsy: // Clinical and Basic Perspectives... 317 // Jordan S. Farrell, Marshal D. Wolff, and G. Campbell Teskey // 13 Prion Diseases... 335 // Benjamin C. Whitechurch, Jeremy M. Welton, // Steven J. Collins, and Victoria A. Lawson // 14 Leukodystrophy: Basic and Clinical... 365 // Gerald V. Raymond // 15 Traumatic Brain Injury as a Trigger of Neurodegeneration... 383 // Victoria E. Johnson, William Stewart, John D. Arena, and Douglas H. Smith // Part III Key Background and Key Technologies // 16 Cell Death Mechanisms of Neurodegeneration... 403 // Jing Fan, Ted M. Dawson, and Valina L. Dawson // 17 Neuroglia: Functional Paralysis and Reactivity in Alzheimer’s // Disease and Other Neurodegenerative Pathologies... 427 // Alexei Verkhratsky, Robert Zorec, J J. Rodriguez, and Vladimir Parpura // 18 Advances in Neuroimaging for Neurodegenerative Disease... 451 // Michele Veldsman and Natalia Egorova // 19 Gene Linkage and Systems Biology... 479 // Mark R. Cookson // 20 Biomarkers in Neurodegenerative Diseases... 491 // Andreas Jerom in and Robert Bowser // Erratum to... El // Index // 529