.

0 (hodnocen0 x )

EB

EB

ONLINE

Cham : Springer International Publishing, 2017

1 online zdroj

ISBN 978-3-319-42252-7 (e-kniha)

ISBN 978-3-319-42251-0 (print)

Progress in Inflammation Research

Preface -- Targeted drug delivery -- I. Bispecific antibodies -- II. Targeting neovessels with NGR peptides -- Genomic-based drugs -- III. Micro-RNA/aptamers -- Nanomedicine -- IV. Exosomes -- V. Microparticles -- Cross-functional targets -- VI. Metabolic targets in inflammation -- VII. Targeting gut microbiome-immune system interactions -- VIII. Targeting the nervous system as an add on therapy for autoinflammatory conditions -- Biomarkers -- IX. Biomarkers in drug discovery -- Other therapies -- X. Stem cell therapy in the treatment of rheumatic disease and application in the treatment of systemic lupus erythematosus.

As our understanding of immune mediated chronic inflammatory diseases (IMIDs) grows, it becomes more and more clear that these conditions result from the convergence of a multitude of pathogenic mechanisms whose relative individual contribution is different in different patient subsets. Promising new technologies have been conceived that address the hypotheses that targeting multiple pathways simultaneously, selectively delivering therapeutics to areas of inflammation and/or resetting the immune system, could take efficacy to new levels. However, we have long waited for the arrival of some of these technologies to the bedside, or even far enough in the drug development process in spite of the initial enthusiasm. Some of the examples covered in this book include bispecific antibodies and genomic medicines, microparticles and targeted delivery of drugs to inflamed vasculature.-.

* Immune-mediated inflammatory diseases * IMID

001475099