.

0 (hodnocen0 x )

EB

EB

ONLINE

Cham : Springer, 2017

1 online zdroj

ISBN 978-3-319-47518-9 (e-kniha)

ISBN 978-3-319-47517-2 (print)

Since its inception 14 years ago, CAPRISA has conducted numerous clinical studies that have influenced international TB-HIV treatment guidelines as well as HIV prevention through innovations in the microbicide and vaccine fields. This book provides a historical account of how each of CAPRISA’s high impact studies was created, developed, implemented, analysed and communicated. In doing so, the reader is taken on a journey that provides glimpses into the genesis of research ideas and how this ultimately leads to a range of HIV prevention and treatment studies that have impacted the global response to the HIV and TB epidemics. The CAPRISA Clinical Trials: HIV Treatment and Prevention is a resource for undergraduate and postgraduate students, health care providers, doctors, decision-makers and researchers who are seeking guidance and insights on clinical trials – their creation, conduct and impact..

001475578

Part I. Introduction -- Studies Linked to the Evolving HIV Epidemic in South Africa: Informing the CAPRISA Scientific Agenda -- CAPRISA: Establishing A Research Center to Undertake HIV Clinical Trials -- Overview of Clinical Trials -- Part II. CAPRISA Clinical Trials for HIV and HSV-2 Prevention -- Antiretrovirals for HIV Prevention -- Rolling out of tenofovir gel in family planning clinics: the CAPRISA 008 implementation trial -- Conditional cash transfers to reduce HIV risk in young women: the CAPRISA 007 cluster randomised control trial -- HIV vaccine and passive immunity trials -- Part III: CAPRISA Clinical Trials for HIV–TB Treatment -- CAPRISA 003: Timing of antiretroviral initiation in HIV-TB co-infected patients - The SAPiT Trial -- Scaling up TB-HIV integration in public health clinics: translating research findings into practice -- Part IV: Experiences and lessons learnt from clinical trials in CAPRISA -- Lessons from the Acute Infection Study: from Bench to Bedside -- Understanding sexual HIV transmission in women by focusing on the genital mucosa -- Part V: Essential support activities for the conduct of clinical trials -- Good practices in conducting clinical trials: Good Participatory Practice, Good Pharmacy Practice and Good Laboratory Practice -- Grants Management -- Taking science to the people: communication and media strategies for clinical trials -- Looking ahead: What Does the Future Hold for CAPRISA? -- Appendix -- Index