1. Introduction / Bradley Layton and Kayla Nagle -- 2. Mechanics of single molecules and single proteins / Alan Hunt, Blake Charlebois, and Seth McCubbin -- 3. Nucleus mechanics / Kris Noel Dahl and Markus J. Buehler -- 4. Nanoscale imaging and modeling / Bradley E. Layton, M. Brent Boyd, and Kathleen B. Allen -- 5. Cell-substrate interactions / Rebecca Lownes Urbano and Alisa Morss Clyne -- 6. Axonal transport and neuromechanics / Sameer B. Shah, Joshua Chetta, and Brian G. Bober -- 7. Implications for disease : valvular fibrosis and the myofibroblast / Mark C. Blaser and Craig A. Simmons.